Evaluation of epidemiological, clinical and laboratory findings in Henoch Schönlein purpura

Abstract

Objective: The aim of this study was to evaluate the presentation, clinical and pathological manifestation and prognosis of patients with Henoch Schönlein purpura.

Methods: 364 cases who were diagnosed with Henoch Schönlein purpura between April 2005-2011 was evaluated retrospectively. Demographic properties of patients, systemic effects of disease, laboratory findings and organ involvement and clinical outcome were investigated.

Results: The patients consisted of 56.3% males (n=205) and 43.7% females (n=159) with the mean age of 8.32±3.38 years. 57.1% (n=208) of the patients had joint involvement, 50.8% (n=185) gastrointestinal involvement, 29.7 %(n=108) renal involvement,1.3 % (n=5) scrotal and 0.8% (n=3) central nerve system. Familial Mediterranean Fever was present in 4.1% (n = 15) of the patients. While age and thrombocytosis were found to be risk factors for renal involvement, leukocytosis was a risk factor for gastrointestinal involvement.

Conclusion: In our study, the most common clinical manifestation was purpuric skin lesions followed by joint involvement. Renal involvement was detected in %29.7 of the patients. Our findings revealed that age and thrombocytosis were risk factors for renal involvement where as leukocytosis was found to be a risk for gastrointestinal involvement.